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China for White Powder Tetracaine Hcl Intermediate Epalrestat intermediate cas 5718-83-2 export to China Hong Kong Suppliers

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Teamwork is encouraged at all levels with regular campaigns. Our research team experiments on various developments in the industry for Eabeth Impurity Cas 82159-09-9,Epatat Intermediate Cas 101-39-3,Carboxymethyl Rhodanine Antidiabetic. we should do our utmost to aid you. We warmly welcome prospects from everywhere in the entire world to cooperate with us for mutual enhancement.

China for White Powder Tetracaine Hcl Intermediate Epalrestat intermediate cas 5718-83-2 export to China Hong Kong Suppliers

Chemical Name: Rhodanine-3-acetic acid
Molecular Formula: C5H5NO3S2
Formula Weight: 191.23
CAS No.: 5718-83-2

5718-83-2



Chemical Name: Epalrestat

Molecular Formula: C15H13NO3S2

Formula Weight: 319.4

CAS No.: 82159-09-9

 82159-09-9

Chemical Name: alpha-Methylcinnamaldehyde

Molecular Formula: C10H10O

Formula Weight: 146.19

CAS No.: 101-39-3

101-39-3
Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy. It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available. It is easily absorbed into the neural tissue and inhibits the enzyme with minimum side effects.


 

"Innovation, excellent and reliability are the core values of our company. These principles today much more than ever form the basis of our success as an internationally active mid-size business for Epalrestat intermediate cas 5718-83-2. The product will supply to all over the world, such as: Cuba,Montserrat,Ukraine. Satisfaction and good credit to every customer is our priority. We focus on every detail of order processing for customers till they have received safe and sound solutions with good logistics service and economical cost. Depending on this our solutions are sold very well in the countries in Africa the Mid-East and Southeast Asia.

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