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Our primary intention should be to offer our clientele a serious and responsible enterprise relationship, delivering personalized attention to all of them for Bupivacaine Base Usp Powder in Stock,Bupivacaine Injection Pharm Grade 99%,Bupivacaine Base Anesthetic Pharmaceuticals. Welcome to post your sample and color ring to let us produce according to your specification.Welcome your inquiry! Looking forward to building long-term cooperation with you!
CAS NO.: 2180-92-9
Molecular Formula: C18H28N2O
Molecular Weight: 288.43
Description: White crystal or crystalline powder
Chemical names, synonyms:
MARCAINE, BUPIVACAINE, BUPIVACAINE BASE, Anekain, Carbostesin, DL-Bupivacaine, LAC-43, WIN 11318, win11318
Minimum purity: 99%
Bupivacaine is a widely used local anesthetic agent.
Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
Pharmacology from NCIt
Bupivacaine is only found in individuals that have used or taken this drug. It is a widely used local anesthetic agent. [PubChem]Bupivacaine blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.
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