Product name: Apixaban
Chemical names,synonyms: Eliquis,Apixaban API, BMS 562247-01,Apixaban, >=99%
CAS Number: 503612-47-3
Molecular Formula: C25H25N5O4
Molecular Weight: 459.5 g.mol-1
Package: foil bag, drum
Minimum purity: 99.0 %
Appearance: Off white powder
Solubility: Sligthly soluble in Acetonitrile or Methanol , soluble in Dimethyl sulfoxide
Apixaban acts by directly inhibiting, in a reversible manner, free and clot-bound factor Xa to inhibit coagulation.
Apixaban is a new form of oral anticoagulant drug developed by Bristol Myers Squibb and Pfizer. It is a new form of oral Xa factor inhibitor, and its commercial name is Eliquis. Apixaban is used to treat adult patients undergoing elective hip or knee replacement surgery to prevent venous thromboembolism (VTE)
Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).1 In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.2 Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.
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