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Terbinafine HCL api terbinafine intermeidate cas 78628-80-5

Basic Info

Function: Antibiotic and Antimicrobial Agents

Grade Standard: Medicine Grade

Type: Chemical Reagent

State: Solid

Volatile: Not Volatile

Product Description

Product: Terbinafine HCL

CAS NO.: 78628-80-5

Standard: Bp,usp

Molecular Formula: C21H26ClN

Molecular Weight: 327.89

Description: Off-white or white crystal or crystalline powder

Package: 25KG/drums

Application: Antifungal

Chemical names, synonyms: lamosil, Terbinafine hdyrochloride, Brican, Bricar, Bricaril, Bricyn, KWD 2019, Terbutanline, Tebinaceil

Minimum purity: 99%

Terbinafine HCL 78628-80-5

Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. It can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc. Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.

Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues[1]. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

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