Chemical Name: Entecavir hydrate
Entecavir Monohydrate (200 mg)
Entecavir monohydrate, >=99%
Molecular Formula: C12H17N5O4
Formula Weight: 295.29448
CAS No.: 209216-23-9
Entecavir is a white to off-white powder. It is slightly soluble in water (2.4 mg/mL), and the pH of the saturated solution in water is 7.9 at 25° C ± 0.5° C.
Absorption, after oral administration of this drug among healthy people, the product is rapidly absorbed with the plasma concentration reaching peak (Cmax) at about 0.5 to 1.5 hours. Administrate this drug once pay day with the drug concentration reaching steady-state after 6 to 10 days with the cumulative amount of about two times.
Entecavir hydrate is a new kind of cyclopentyl acyl guanosine anti-hepatitis b virus drugs with its pharmacological effects similar as entecavir. It is clinically applied to the treatment of adult chronic hepatitis b in which there is active viral replication, increased serum transaminase ALT or active lesions showed from liver histology.
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